Immunological Sciences

CD18 Mouse Monoclonal Antibody

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Catalog Number:MABN80739
Conjugate:Unconjugated
Size:100μL
Concentration:1mg/ml
Host:Mouse
Isotype:Mouse IgG2b
Clone:Monoclonal
Immunogen:Purified recombinant fragment of CD18 expressed in E. Coli.
Reactivity:Human,Mouse
Applications:ICC 1:200-1:1000,ELISA 1:5000-1:20000
Molecular Weight:85kDa
Purification:Affinity Purification
Form:Liquid
Synonyms:LAD; MF17; LCAMB; LFA-1; ITGB2

Applications

ICC 1:200-1:1000,ELISA 1:5000-1:20000

Immunogen

Purified recombinant fragment of CD18 expressed in E. Coli.

Target Background

CD18, also known as ITGB2 (integrin beta chain beta 2). Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. For example, beta 2 combines with the alpha L chain to form the integrin LFA-1, and combines with the alpha M chain to form the integrin Mac-1. Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling. CD18 is expressed by most leucocytes. Defects in this gene are the cause of leukocyte adhesion deficiency type I (LAD1). Two transcript variants encoding the same protein have been identified for this gene.

Synonyms:LAD; MF17; LCAMB; LFA-1; ITGB2

Storage

Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.

Buffer

Purified antibody in PBS with 0.05% sodium azide.

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