Immunological Sciences

CD276 Mouse Monoclonal Antibody

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Catalog Number:MABN86113
Conjugate:Unconjugated
Size:100μL
Concentration:1mg/ml
Host:Mouse
Isotype:Mouse IgG1
Clone:Monoclonal
Immunogen:This CD276 antibody is generated from a mouse immunized with a recombinant protein from the human region of human CD276.
Reactivity:Human, Mouse, Rat
Applications:WB 1:1000-1:2000,IHC 1:100-1:500
Molecular Weight:57.2kDa
Purification:Affinity Purification
Form:Liquid
Synonyms:CD276 antigen, 4Ig-B7-H3, B7 homolog 3, B7-H3, Costimulatory molecule, CD276, CD276, B7H3

Applications

WB 1:1000-1:2000,IHC 1:100-1:500

Immunogen

This CD276 antibody is generated from a mouse immunized with a recombinant protein from the human region of human CD276.

Target Background

May participate in the regulation of T-cell-mediated immune response. May play a protective role in tumor cells by inhibiting natural-killer mediated cell lysis as well as a role of marker for detection of neuroblastoma cells. May be involved in the development of acute and chronic transplant rejection and in the regulation of lymphocytic activity at mucosal surfaces. Could also play a key role in providing the placenta and fetus with a suitable immunological environment throughout pregnancy. Both isoform 1 and isoform 2 appear to be redundant in their ability to modulate CD4 T-cell responses. Isoform 2 is shown to enhance the induction of cytotoxic T-cells and selectively stimulates interferon gamma production in the presence of T-cell receptor signaling.

Synonyms:CD276 antigen, 4Ig-B7-H3, B7 homolog 3, B7-H3, Costimulatory molecule, CD276, CD276, B7H3

Storage

Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.

Buffer

Purified antibody in PBS with 0.05% sodium azide.

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