Immunological Sciences

CD31 Rabbit Monoclonal Antibody

No images available

Catalog Number:MABN86771
Conjugate:Unconjugated
Size:100μL
Concentration:1mg/ml
Host:Rabbit
Isotype:IgG
Clone:Monoclonal
Immunogen:Recombinant protein of mouse CD31
Reactivity:Mouse,Rat
Applications:WB 1:500-1:2000,IHC 1:100-1:200,ICC/IF 1:100-1:200
Molecular Weight:Calculated MW:83 kDa; Observed MW:130-135 kDa
Purification:Affinity Purification
Form:Liquid
Synonyms:Cd31; Pecam; C85791; PECAM-1

Applications

WB 1:500-1:2000,IHC 1:100-1:200,ICC/IF 1:100-1:200

Immunogen

Recombinant protein of mouse CD31

Target Background

Cell adhesion molecule which is required for leukocyte transendothelial migration (TEM) under most inflammatory conditions. Tyr-679 plays a critical role in TEM and is required for efficient trafficking of PECAM1 to and from the lateral border recycling compartment (LBRC) and is also essential for the LBRC membrane to be targeted around migrating leukocytes. Prevents phagocyte ingestion of closely apposed viable cells by transmitting 'detachment' signals, and changes function on apoptosis, promoting tethering of dying cells to phagocytes (the encounter of a viable cell with a phagocyte via the homophilic interaction of PECAM1 on both cell surfaces leads to the viable cell's active repulsion from the phagocyte. During apoptosis, the inside-out signaling of PECAM1 is somehow disabled so that the apoptotic cell does not actively reject the phagocyte anymore.

Synonyms:Cd31; Pecam; C85791; PECAM-1

Storage

Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.

Buffer

Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.

No documents available.