Immunological Sciences

CD35 (4U8) Rabbit Monoclonal Antibody

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Catalog Number:MABN08375
Conjugate:Unconjugated
Size:100μL
Concentration:1mg/ml
Host:Rabbit
Isotype:IgG
Clone:Monoclonal
Immunogen:A synthetic peptide of human CD35
Reactivity:Human
Applications:WB 1:1000-1:5000,IHC 1:200-1:500
Molecular Weight:224kDa
Purification:Affinity purification
Form:Liquid
Synonyms:C3 binding protein; C3b/C4b receptor; C3BR; C4BR; CD35; CR1; KN;

Applications

WB 1:1000-1:5000,IHC 1:200-1:500

Immunogen

A synthetic peptide of human CD35

Target Background

Mediates cellular binding of particles and immune complexes that have activated complement. Membrane immune adherence receptor that plays a critical role in the capture and clearance of complement-opsonized pathogens by erythrocytes and monocytes/macrophages (PubMed:2963069). Mediates the binding by these cells of particles and immune complexes that have activated complement to eliminate them from the circulation (PubMed:2963069). Acts also in the inhibition of spontaneous complement activation by impairing the formation and function of the alternative and classical pathway C3/C5 convertases, and by serving as a cofactor for the cleavage by factor I of C3b to iC3b, C3c and C3d,g, and of C4b to C4c and C4d (PubMed:2972794, PubMed:8175757). Plays also a role in immune regulation by contributing, upon ligand binding, to the generation of regulatory T cells from activated helper T cells (PubMed:25742728).

Synonyms:C3 binding protein; C3b/C4b receptor; C3BR; C4BR; CD35; CR1; KN;

Storage

Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.

Buffer

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.

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