Immunological Sciences

CD41 Rabbit Monoclonal Antibody

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Catalog Number:MABN86831
Conjugate:Unconjugated
Size:100μL
Concentration:1mg/ml
Host:Rabbit
Isotype:IgG
Clone:Monoclonal
Immunogen:Recombinant protein of mouse CD41
Reactivity:Mouse,Rat
Applications:WB 1:500-1:2000,IHC 1:200-1:500
Molecular Weight:Calculated MW:113 kDa; Observed MW:113 kDa
Purification:Affinity Purification
Form:Liquid
Synonyms:CD41; CD41B; GpIIb; AI172977; alphaIIb

Applications

WB 1:500-1:2000,IHC 1:200-1:500

Immunogen

Recombinant protein of mouse CD41

Target Background

Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. It recognizes the sequence R-G-D in a wide array of ligands. It recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial cell surface.

Synonyms:CD41; CD41B; GpIIb; AI172977; alphaIIb

Storage

Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.

Buffer

Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.

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