Immunological Sciences

CD45 (15N7) Rabbit Monoclonal Antibody

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Catalog Number:MABN08402
Conjugate:Unconjugated
Size:100μL
Concentration:1mg/ml
Host:Rabbit
Isotype:IgG
Clone:Monoclonal
Immunogen:A synthetic peptide of human CD45
Reactivity:Human
Applications:WB 1:1000-1:5000,IHC 1:100-1:200,ICC/IF 1:100-1:200,FC 1:20-1:50
Molecular Weight:147kDa
Purification:Affinity purification
Form:Liquid
Synonyms:CD45; B220; GP180; LCA; PTPRC; T200 leukocyte common antigen;

Applications

WB 1:1000-1:5000,IHC 1:100-1:200,ICC/IF 1:100-1:200,FC 1:20-1:50

Immunogen

A synthetic peptide of human CD45

Target Background

Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits and dephosphorylates SKAP1 and FYN. Dephosphorylates LYN, and thereby modulates LYN activity (By similarity). Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits and dephosphorylates SKAP1 and FYN. Dephosphorylates LYN, and thereby modulates LYN activity (By similarity).

Synonyms:CD45; B220; GP180; LCA; PTPRC; T200 leukocyte common antigen;

Storage

Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.

Buffer

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.

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