Immunological Sciences

CD45 Mouse Monoclonal Antibody

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Catalog Number:MABN85077
Conjugate:Unconjugated
Size:100μL
Concentration:1mg/ml
Host:Mouse
Isotype:Mouse IgG1
Clone:Monoclonal
Immunogen:Synthetic Peptide of CD45
Reactivity:Human
Applications:WB 1:500-1:1000,IHC 1:50-1:100,ICC 1:50-1:200
Molecular Weight:Calculated MW: 145 kDa; Observed MW: 145 kDa
Purification:Affinity Purification
Form:Liquid
Synonyms:GP180; L CA; CD45 antigen

Applications

WB 1:500-1:1000,IHC 1:50-1:100,ICC 1:50-1:200

Immunogen

Synthetic Peptide of CD45

Target Background

Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits and dephosphorylates SKAP1 and FYN . Dephosphorylates LYN, and thereby modulates LYN activity.

Synonyms:GP180; L CA; CD45 antigen

Storage

Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.

Buffer

Purified antibody in PBS with 0.05% sodium azide,0.5%BSA and 50% glycerol.

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