CD46 Mouse Monoclonal Antibody

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Catalog Number:MABN82106
Conjugate:Unconjugated
Size:100μL
Concentration:1mg/ml
Host:Mouse
Isotype:Mouse IgG1
Clone:Monoclonal
Immunogen:Purified recombinant fragment of human CD46 (AA: extra 35-179) expressed in E. Coli.
Reactivity:Human
Applications:WB 1:500-1:2000,ICC 1:100-1:500,ELISA 1:5000-1:20000,FC 1:200-1:400
Molecular Weight:43.7kDa
Purification:Affinity Purification
Form:Liquid
Synonyms:MCP; TLX; AHUS2; MIC10; TRA2.10

Applications

WB 1:500-1:2000,ICC 1:100-1:500,ELISA 1:5000-1:20000,FC 1:200-1:400

Immunogen

Purified recombinant fragment of human CD46 (AA: extra 35-179) expressed in E. Coli.

Target Background

The protein encoded by this gene is a type I membrane protein and is a regulatory part of the complement system. The encoded protein has cofactor activity for inactivation of complement components C3b and C4b by serum factor I, which protects the host cell from damage by complement. In addition, the encoded protein can act as a receptor for the Edmonston strain of measles virus, human herpesvirus-6, and type IV pili of pathogenic Neisseria. Finally, the protein encoded by this gene may be involved in the fusion of the spermatozoa with the oocyte during fertilization. Mutations at this locus have been associated with susceptibility to hemolytic uremic syndrome. Alternatively spliced transcript variants encoding different isoforms have been described.

Synonyms:MCP; TLX; AHUS2; MIC10; TRA2.10

Storage

Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.

Buffer

Purified antibody in PBS with 0.05% sodium azide

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