Immunological Sciences

CDT1 (3N6) Rabbit Monoclonal Antibody

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Catalog Number:MABN08589
Conjugate:Unconjugated
Size:100μL
Concentration:1mg/ml
Host:Rabbit
Isotype:IgG
Clone:Monoclonal
Immunogen:Recombinant protein of human CDT1
Reactivity:Human
Applications:WB 1:500-1:2000,IHC 1:50-1:200,ICC/IF 1:100-1:200,IP 1:20-1:50
Molecular Weight:60kDa
Purification:Affinity purification
Form:Liquid
Synonyms:CDT 1; Chromatin licensing and DNA replication factor 1; Retroviral integration site 2; RIS2;

Applications

WB 1:500-1:2000,IHC 1:50-1:200,ICC/IF 1:100-1:200,IP 1:20-1:50

Immunogen

Recombinant protein of human CDT1

Target Background

Cooperates with CDC6 to promote the loading of the mini-chromosome maintenance complex onto chromatin to form the pre-replication complex necessary to initiate DNA replication. Binds DNA in a sequence-, strand-, and conformation-independent manner. Potential oncogene. Required for both DNA replication and mitosis (PubMed:11125146, PubMed:22581055, PubMed:21856198, PubMed:14993212, PubMed:26842564). DNA replication licensing factor, required for pre- replication complex assembly. Cooperates with CDC6 and the origin recognition complex (ORC) during G1 phase of the cell cycle to promote the loading of the mini-chromosome maintenance (MCM) complex onto DNA to generate pre-replication complexes (pre-RC)(PubMed:14672932). Required also for mitosis by promoting stable kinetochore-microtubule attachments (PubMed:22581055). Potential oncogene (By similarity).

Synonyms:CDT 1; Chromatin licensing and DNA replication factor 1; Retroviral integration site 2; RIS2;

Storage

Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.

Buffer

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.

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