Immunological Sciences

Chk2 Rabbit Monoclonal Antibody

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Catalog Number:MABN85432
Conjugate:Unconjugated
Size:100μL
Concentration:1mg/ml
Host:Rabbit
Isotype:IgG
Clone:Monoclonal
Immunogen:Recombinant protein of human Chk2
Reactivity:Human
Applications:WB 1:500-1:1000,ICC 1:50-1:200,IP 1:10-1:20
Molecular Weight:Calculated MW: 61 kDa; Observed MW: 61 kDa
Purification:Affinity Purification
Form:Liquid
Synonyms:CHEK2; CDS1; CHK2; RAD53; Serine/threonine-protein kinase Chk2; CHK2 checkpoint homolog; Cds1 homolog; Hucds1; hCds1; Checkpoint kinase 2

Applications

WB 1:500-1:1000,ICC 1:50-1:200,IP 1:10-1:20

Immunogen

Recombinant protein of human Chk2

Target Background

These are known to be preferred sites for phosphorylation by ATM/ATR kinases. After DNA damage by ionizing radiation (IR), UV irradiation, or hydroxyurea treatment, Thr68 and other sites in this region become phosphorylated by ATM/ATR. The SQ/TQ cluster domain, therefore, seems to have a regulatory function.

Synonyms:CHEK2; CDS1; CHK2; RAD53; Serine/threonine-protein kinase Chk2; CHK2 checkpoint homolog; Cds1 homolog; Hucds1; hCds1; Checkpoint kinase 2

Storage

Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.

Buffer

Purified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol.

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