Immunological Sciences

Cip4 Rabbit Monoclonal Antibody

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Catalog Number:MABN86493
Conjugate:Unconjugated
Size:100μL
Concentration:1mg/ml
Host:Rabbit
Isotype:IgG
Clone:Monoclonal
Immunogen:A synthetic peptide of human Cip4
Reactivity:Human,Mouse,Rat
Applications:WB 1:1000-1:5000,IHC 1:100-1:200
Molecular Weight:Calculated MW:68 kDa; Observed MW:80 kDa
Purification:Affinity Purification
Form:Liquid
Synonyms:STP; CIP4; HSTP; STOT; TRIP-10

Applications

WB 1:1000-1:5000,IHC 1:100-1:200

Immunogen

A synthetic peptide of human Cip4

Target Background

Required for translocation of GLUT4 to the plasma membrane in response to insulin signaling (By similarity). Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during endocytosis. Binds to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promotes membrane invagination and the formation of tubules. Also promotes CDC42-induced actin polymerization by recruiting WASL/N-WASP which in turn activates the Arp2/3 complex. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. Required for the formation of podosomes, actin-rich adhesion structures specific to monocyte-derived cells. May be required for the lysosomal retention of FASLG/FASL.

Synonyms:STP; CIP4; HSTP; STOT; TRIP-10

Storage

Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.

Buffer

Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.

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