Immunological Sciences

Cleaved-ITI-H4 70k (R661) Rabbit Polyclonal Antibody

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Catalog Number:ABN09001
Conjugate:Unconjugated
Size:100μL
Concentration:1mg/ml
Host:Rabbit
Isotype:IgG
Clone:Polyclonal
Immunogen:The antiserum was produced against synthesized peptide derived from human ITIH4. AA range:612-661
Reactivity:Human,Rat,Mouse
Applications:IHC 1:100-1:300,ICC/IF 1:50-1:200,ELISA 1:5000-1:20000
Purification:Affinity purification
Form:Liquid
Synonyms:ITIH4; IHRP; ITIHL1; PK120; Inter-alpha-trypsin inhibitor heavy chain H4; ITI heavy chain H4; ITI-HC4; Inter-alpha-inhibitor heavy chain 4; Inter-alpha-trypsin inhibitor family heavy chain-related protein; IHRP; Plasma kallikrein sensitive

Applications

IHC 1:100-1:300,ICC/IF 1:50-1:200,ELISA 1:5000-1:20000

Immunogen

The antiserum was produced against synthesized peptide derived from human ITIH4. AA range:612-661

Target Background

The protein encoded by this gene is secreted into the blood, where it is cleaved by plasma kallikrein into two smaller forms. Expression of this gene has been detected only in liver, and it seems to be upregulated during surgical trauma. This gene is part of a cluster of similar genes on chromosome 3. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009],function:May be involved in acute phase reactions.,induction:Levels increase significantly in the sera of patients after different surgical trauma.,PTM:Appears to be both N- and O-glycosylated.,PTM:Cleaved by plasma kallikrein to yield 100 kDa and 35 kDa fragments, and the resulting 100 kDa fragment is further converted to a 70 kDa fragment.,PTM:The O-linked polysaccharides on Ser-696, Thr-701 and Ser-702 are probably the mucin type linked to GalNAc.,similarity:Belongs to the ITIH family.,similarity:Contains 1 VWFA domain.,tissue specificity:Liver specific.,

Synonyms:ITIH4; IHRP; ITIHL1; PK120; Inter-alpha-trypsin inhibitor heavy chain H4; ITI heavy chain H4; ITI-HC4; Inter-alpha-inhibitor heavy chain 4; Inter-alpha-trypsin inhibitor family heavy chain-related protein; IHRP; Plasma kallikrein sensitive

Storage

Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.

Buffer

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.

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