CNOT7 Rabbit Monoclonal Antibody

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Catalog Number:MABN86524
Conjugate:Unconjugated
Size:100μL
Concentration:1mg/ml
Host:Rabbit
Isotype:IgG
Clone:Monoclonal
Immunogen:A synthetic peptide of mouse CNOT7
Reactivity:Human,Mouse,Rat
Applications:WB 1:500-1:2000,ICC/IF 1:500-1:1000,FC 1:200-1:1000,IP 1:20-1:50
Molecular Weight:Calculated MW:33 kDa; Observed MW:33 kDa
Purification:Affinity Purification
Form:Liquid
Synonyms:Caf1; Pop2; CAF-1; AU022737

Applications

WB 1:500-1:2000,ICC/IF 1:500-1:1000,FC 1:200-1:1000,IP 1:20-1:50

Immunogen

A synthetic peptide of mouse CNOT7

Target Background

Has 3'-5' poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Its function seems to be partially redundant with that of CNOT8. Catalytic component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. During miRNA-mediated repression the complex seems also to act as translational repressor during translational initiation. Additional complex functions may be a consequence of its influence on mRNA expression. Required for miRNA-mediated mRNA deadenylation.

Synonyms:Caf1; Pop2; CAF-1; AU022737

Storage

Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.

Buffer

Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.

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