COPS3 Rabbit Monoclonal Antibody

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Catalog Number:MABN84547
Conjugate:Unconjugated
Size:100μL
Concentration:1mg/ml
Host:Rabbit
Isotype:IgG
Clone:Monoclonal
Immunogen:A synthesized peptide derived from human COPS3
Reactivity:Human,Mouse,Rat
Applications:WB 1:1000-1:2000,ICC 1:50-1:200,FC 1:20-1:100,IP 1:20-1:50
Molecular Weight:48 kDa
Purification:Affinity Purification
Form:Liquid
Synonyms:COP9 subunit 3; cops3; CSN3; JAB 1 containing signalosome subunit 3; SGN3; Signalosome subunit 3;;COPS3

Applications

WB 1:1000-1:2000,ICC 1:50-1:200,FC 1:20-1:100,IP 1:20-1:50

Immunogen

A synthesized peptide derived from human COPS3

Target Background

Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases.

Synonyms:COP9 subunit 3; cops3; CSN3; JAB 1 containing signalosome subunit 3; SGN3; Signalosome subunit 3;;COPS3

Storage

Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.

Buffer

Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol.

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