Immunological Sciences

CREB (8X7) Rabbit Monoclonal Antibody

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Catalog Number:MABN09374
Conjugate:Unconjugated
Size:100μL
Concentration:1mg/ml
Host:Rabbit
Isotype:IgG
Clone:Monoclonal
Immunogen:A synthetic peptide of human CREB
Reactivity:Human,Mouse,Rat
Applications:WB 1:500-1:2000,IHC 1:200-1:500,IF-P 1:200-1:500
Molecular Weight:35kDa
Purification:Affinity purification
Form:Liquid
Synonyms:cAMP responsive element binding protein 1; cAMP-respconse element binding protein; CREB-1; CREB1

Applications

WB 1:500-1:2000,IHC 1:200-1:500,IF-P 1:200-1:500

Immunogen

A synthetic peptide of human CREB

Target Background

This gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. This protein binds as a homodimer to the cAMP-responsive element, an octameric palindrome. The protein is phosphorylated by several protein kinases, and induces transcription of genes in response to hormonal stimulation of the cAMP pathway. Alternate splicing of this gene results in two transcript variants encoding different isoforms. Phosphorylation-dependent transcription factor that stimulates transcription upon binding to the DNA cAMP response element (CRE), a sequence present in many viral and cellular promoters. Transcription activation is enhanced by the TORC coactivators which act independently of Ser-119 phosphorylation. Involved in different cellular processes including the synchronization of circadian rhythmicity and the differentiation of adipose cells.

Synonyms:cAMP responsive element binding protein 1; cAMP-respconse element binding protein; CREB-1; CREB1

Storage

Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.

Buffer

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.

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