Immunological Sciences

CRM1 Rabbit Monoclonal Antibody

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Catalog Number:MABN85456
Conjugate:Unconjugated
Size:100μL
Concentration:1mg/ml
Host:Rabbit
Isotype:IgG
Clone:Monoclonal
Immunogen:A synthetic peptide of human CRM1
Reactivity:Human,Mouse,Rat
Applications:WB 1:500-1:1000,IHC 1:50-1:100,ICC 1:50-1:200
Molecular Weight:Calculated MW: 123 kDa; Observed MW: 123 kDa
Purification:Affinity Purification
Form:Liquid
Synonyms:XPO1; CRM1; Exportin-1; Exp1; Chromosome region maintenance 1 protein homolog

Applications

WB 1:500-1:1000,IHC 1:50-1:100,ICC 1:50-1:200

Immunogen

A synthetic peptide of human CRM1

Target Background

Mediates the nuclear export of cellular proteins (cargos) bearing a leucine-rich nuclear export signal (NES) and of RNAs. In the nucleus, in association with RANBP3, binds cooperatively to the NES on its target protein and to the GTPase RAN in its active GTP-bound form (Ran-GTP). Docking of this complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins.

Synonyms:XPO1; CRM1; Exportin-1; Exp1; Chromosome region maintenance 1 protein homolog

Storage

Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.

Buffer

Purified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol.

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