CRTC3 Rabbit Monoclonal antibody

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Catalog Number:MABN01479
Conjugate:Unconjugated
Size:100μL
Concentration:1mg/ml
Host:Rabbit
Isotype:IgG
Clone:Monoclonal
Immunogen:A synthetic peptide of human CRTC3
Reactivity:Human,Mouse,Rat
Applications:WB 1:500-1:1000,ICC/IF 1:50-1:200
Molecular Weight:Calculated MW: 67 kDa; Observed MW: 78 kDa
Purification:Affinity Purified
Form:Liquid
Synonyms:TORC3; FLJ21868; CRTC3

Applications

WB 1:500-1:1000,ICC/IF 1:50-1:200

Immunogen

A synthetic peptide of human CRTC3

Target Background

Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR) .Tissue specificity: Predominantly expressed in B and T lymphocytes. Highest levels in lung. Also expressed in brain, colon, heart, kidney, ovary, and prostate. Weak expression in liver, pancreas, muscle, small inTine, spleen and stomach.

Synonyms:TORC3; FLJ21868; CRTC3

Storage

Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.

Buffer

50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA

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