Cyclin E2 Rabbit Monoclonal Antibody

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Catalog Number:MABN85474
Conjugate:Unconjugated
Size:100μL
Concentration:1mg/ml
Host:Rabbit
Isotype:IgG
Clone:Monoclonal
Immunogen:A synthetic peptide of human Cyclin E2
Reactivity:Human
Applications:WB 1:500-1:1000,IHC 1:50-1:100,ICC 1:50-1:200
Molecular Weight:Calculated MW: 47 kDa; Observed MW: 47 kDa
Purification:Affinity Purification
Form:Liquid
Synonyms:CCNE2; G1/S-specific cyclin-E2

Applications

WB 1:500-1:1000,IHC 1:50-1:100,ICC 1:50-1:200

Immunogen

A synthetic peptide of human Cyclin E2

Target Background

The human Cyclin E2 gene encodes a 404 amino acid protein that is most closely related to Cyclin E. Cyclin E2 mRNA levels peaks at the G1 / S transition. Cyclin E2 associates with Cdk2 in a functional kinase complex that is inhibited by both p27 (Kip1) and p21 (Cip1). Cyclin E2 / Cdk2 phosphorylates histone H1 in vitro. G1 cyclin E controls the initiation of DNA synthesis by activating CDK2. Abnormally high levels of cyclin E expression have frequently been observed in human cancers.

Synonyms:CCNE2; G1/S-specific cyclin-E2

Storage

Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.

Buffer

Purified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol.

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