Immunological Sciences

Cyclin H Mouse Monoclonal Antibody

No images available

Catalog Number:MABN85049
Conjugate:Unconjugated
Size:100μL
Concentration:1mg/ml
Host:Mouse
Isotype:Mouse IgG2b
Clone:Monoclonal
Immunogen:Purified recombinant human Cyclin H protein fragments expressed in E.coli.
Reactivity:Human,Mouse
Applications:WB 1:500-1:1000
Molecular Weight:Calculated MW: 38 kDa; Observed MW: 38 kDa
Purification:Affinity Purification
Form:Liquid
Synonyms:CCNH; Cyclin-H; MO15-associated protein; p34; p37

Applications

WB 1:500-1:1000

Immunogen

Purified recombinant human Cyclin H protein fragments expressed in E.coli.

Target Background

Regulates CDK7, the catalytic subunit of the CDK-activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II. Its expression and activity are constant throughout the cell cycle.

Synonyms:CCNH; Cyclin-H; MO15-associated protein; p34; p37

Storage

Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.

Buffer

Purified antibody in PBS with 0.05% sodium azide,0.5%BSA and 50% glycerol.

No documents available.