CYFIP1 Rabbit Monoclonal Antibody

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Catalog Number:MABN85477
Conjugate:Unconjugated
Size:100μL
Concentration:1mg/ml
Host:Rabbit
Isotype:IgG
Clone:Monoclonal
Immunogen:A synthetic peptide of human CYFIP1
Reactivity:Human,Mouse,Rat
Applications:WB 1:500-1:1000
Molecular Weight:Calculated MW: 145 kDa; Observed MW: 145 kDa
Purification:Affinity Purification
Form:Liquid
Synonyms:SHYC; SRA1; SRA-1; P140SRA-1

Applications

WB 1:500-1:1000

Immunogen

A synthetic peptide of human CYFIP1

Target Background

Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit is an adapter between EIF4E and FMR1. Promotes the translation repression activity of FMR1 in brain probably by mediating its association with EIF4E and mRNA . Regulates formation of membrane ruffles and lamellipodia. Plays a role in axon outgrowth. Binds to F-actin but not to RNA. Part of the WAVE complex that regulates actin filament reorganization via its interaction with the Arp2/3 complex. Actin remodeling activity is regulated by RAC1. Regulator of epithelial morphogenesis. As component of the WAVE1 complex, required for BDNF-NTRK2 endocytic trafficking and signaling from early endosomes . May act as an invasion suppressor in cancers.

Synonyms:SHYC; SRA1; SRA-1; P140SRA-1

Storage

Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.

Buffer

Purified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol.

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