Immunological Sciences

DGCR8 Rabbit Monoclonal Antibody

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Catalog Number:MABN85504
Conjugate:Unconjugated
Size:100μL
Concentration:1mg/ml
Host:Rabbit
Isotype:IgG
Clone:Monoclonal
Immunogen:Recombinant protein of human DGCR8
Reactivity:Human,Mouse,Rat
Applications:WB 1:500-1:1000,ICC 1:50-1:200,IP 1:10-1:20
Molecular Weight:Calculated MW: 86 kDa; Observed MW: 120 kDa
Purification:Affinity Purification
Form:Liquid
Synonyms:DGCR8; DGCRK6; Gy1; C22orf12; D16Wis2; pasha

Applications

WB 1:500-1:1000,ICC 1:50-1:200,IP 1:10-1:20

Immunogen

Recombinant protein of human DGCR8

Target Background

Component of the microprocessor complex that is required to process primary miRNA transcripts (pri-miRNAs) to release precursor miRNA (pre-miRNA) in the nucleus. Within the microprocessor complex, DGCR8 function as a molecular anchor necessary for the recognition of pri-miRNA at dsRNA-ssRNA junction and directs DROSHA to cleave 11 bp away form the junction to release hairpin-shaped pre-miRNAs that are subsequently cut by the cytoplasmic DICER to generate mature miRNAs.

Synonyms:DGCR8; DGCRK6; Gy1; C22orf12; D16Wis2; pasha

Storage

Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.

Buffer

Purified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol.

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