Immunological Sciences

DKK1 Rabbit Monoclonal Antibody

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Catalog Number:MABN86718
Conjugate:Unconjugated
Size:100μL
Concentration:1mg/ml
Host:Rabbit
Isotype:IgG
Clone:Monoclonal
Immunogen:A synthetic peptide of human DKK1
Reactivity:Human
Applications:WB 1:1000-1:5000,IHC 1:200-1:1000
Molecular Weight:Calculated MW:29 kDa; Observed MW:28-40 kDa
Purification:Affinity Purification
Form:Liquid
Synonyms:SK; DKK-1

Applications

WB 1:1000-1:5000,IHC 1:200-1:1000

Immunogen

A synthetic peptide of human DKK1

Target Background

This gene encodes a member of the dickkopf family of proteins. Members of this family are secreted proteins characterized by two cysteine-rich domains that mediate protein-protein interactions. The encoded protein binds to the LRP6 co-receptor and inhibits beta-catenin-dependent Wnt signaling. This gene plays a role in embryonic development and may be important in bone formation in adults. Elevated expression of this gene has been observed in numerous human cancers and this protein may promote proliferation, invasion and growth in cancer cell lines. [provided by RefSeq, Sep 2017]

Synonyms:SK; DKK-1

Storage

Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.

Buffer

Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.

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