Immunological Sciences

Dnmt1 Rabbit Monoclonal Antibody

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Catalog Number:MABN86343
Conjugate:Unconjugated
Size:100μL
Concentration:1mg/ml
Host:Rabbit
Isotype:IgG
Clone:Monoclonal
Immunogen:A synthetic peptide of human Dnmt1
Reactivity:Human
Applications:WB 1:1000-1:5000,IHC 1:200-1:1000,ICC/IF 1:100-1:200,FC 1:20-1:50
Molecular Weight:Calculated MW:183 kDa; Observed MW:183 kDa
Purification:Affinity Purification
Form:Liquid
Synonyms:AIM; DNMT; MCMT; CXXC9; HSN1E; ADCADN; m.HsaI

Applications

WB 1:1000-1:5000,IHC 1:200-1:1000,ICC/IF 1:100-1:200,FC 1:20-1:50

Immunogen

A synthetic peptide of human Dnmt1

Target Background

This gene encodes an enzyme that transfers methyl groups to cytosine nucleotides of genomic DNA. This protein is the major enzyme responsible for maintaining methylation patterns following DNA replication and shows a preference for hemi-methylated DNA. Methylation of DNA is an important component of mammalian epigenetic gene regulation. Aberrant methylation patterns are found in human tumors and associated with developmental abnormalities. Variation in this gene has been associated with cerebellar ataxia, deafness, and narcolepsy, and neuropathy, hereditary sensory, type IE. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]

Synonyms:AIM; DNMT; MCMT; CXXC9; HSN1E; ADCADN; m.HsaI

Storage

Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.

Buffer

Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.

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