Dnmt3a Rabbit Monoclonal antibody

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Catalog Number:MABN02974
Conjugate:Unconjugated
Size:100μL
Concentration:1mg/ml
Host:Rabbit
Isotype:IgG
Clone:Monoclonal
Immunogen:A synthetic peptide of human Dnmt3a
Reactivity:Human
Applications:WB 1:500-1:1000
Molecular Weight:Calculated MW: 102 kDa; Observed MW: 130 kDa
Purification:Affinity Purified
Form:Liquid
Synonyms:DNMT3A2; M.HsaIIIA; Dnmt3a; MCMT; DNA methyltransferase 3a

Applications

WB 1:500-1:1000

Immunogen

A synthetic peptide of human Dnmt3a

Target Background

Methylation of DNA at cytosine residues in mammalian cells is a heritable, epigenetic modification that is critical for proper regulation of gene expression, genomic imprinting and development. Three families of mammalian DNA methyltransferases have been identified: DNMT1, DNMT2 and DNMT3. DNMT1 is constitutively expressed in proliferating cells and functions as a maintenance methyltransferase, transferring proper methylation patterns to newly synthesized DNA during replication.

Synonyms:DNMT3A2; M.HsaIIIA; Dnmt3a; MCMT; DNA methyltransferase 3a

Storage

Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.

Buffer

50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA

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