DOCK8 Rabbit Monoclonal Antibody

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Catalog Number:MABN01921
Conjugate:Unconjugated
Size:100μL
Concentration:1mg/ml
Host:Rabbit
Isotype:IgG
Clone:Monoclonal
Immunogen:Recombinant protein of human DOCK8
Reactivity:Human
Applications:WB 1:500-1:1000
Molecular Weight:Calculated MW: 239 kDa; Observed MW: 239 kDa
Purification:Affinity Purification
Form:Liquid
Synonyms:MRD2; ZIR8; HEL-205

Applications

WB 1:500-1:1000

Immunogen

Recombinant protein of human DOCK8

Target Background

Guanine nucleotide exchange factor (GEF) which specifically activates small GTPase CDC42 by exchanging bound GDP for free GTP (PubMed:28028151, PubMed:22461490). During immune responses, required for interstitial dendritic cell (DC) migration by locally activating CDC42 at the leading edge membrane of DC . Required for CD4+ T-cell migration in response to chemokine stimulation by promoting CDC42 activation at T cell leading edge membrane (PubMed:28028151). Is involved in NK cell cytotoxicity by controlling polarization of microtubule-organizing center (MTOC), and possibly regulating CCDC88B-mediated lytic granule transport to MTOC during cell killing (PubMed:25762780).

Synonyms:MRD2; ZIR8; HEL-205

Storage

Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.

Buffer

50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA

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