Immunological Sciences

DR5 Rabbit Monoclonal Antibody

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Catalog Number:MABN87759
Conjugate:Unconjugated
Size:100μL
Concentration:1mg/ml
Host:Rabbit
Isotype:IgG
Clone:Monoclonal
Immunogen:Recombinant protein of human DR5
Reactivity:Human
Applications:WB 1:500-1:2000,ICC/IF 1:100-1:200,FC 1:50-1:100,IP 1:20-1:50
Molecular Weight:Calculated MW:49 kDa; Observed MW:40,49 kDa
Purification:Affinity Purification
Form:Liquid
Synonyms:DR5; CD262; KILLER; TRICK2; TRICKB; ZTNFR9; TRAILR2; TRICK2A; TRICK2B; TRAIL-R2; KILLER/DR5

Applications

WB 1:500-1:2000,ICC/IF 1:100-1:200,FC 1:50-1:100,IP 1:20-1:50

Immunogen

Recombinant protein of human DR5

Target Background

The protein encoded by this gene is a member of the TNF-receptor superfamily, and contains an intracellular death domain. This receptor can be activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL/APO-2L), and transduces an apoptosis signal. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein. Two transcript variants encoding different isoforms and one non-coding transcript have been found for this gene. [provided by RefSeq, Mar 2009]

Synonyms:DR5; CD262; KILLER; TRICK2; TRICKB; ZTNFR9; TRAILR2; TRICK2A; TRICK2B; TRAIL-R2; KILLER/DR5

Storage

Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.

Buffer

Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.

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