Immunological Sciences

Drosha Rabbit Monoclonal Antibody

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Catalog Number:MABN87469
Conjugate:Unconjugated
Size:100μL
Concentration:1mg/ml
Host:Rabbit
Isotype:IgG
Clone:Monoclonal
Immunogen:A synthetic peptide of human Drosha
Reactivity:Human
Applications:WB 1:2000-1:20000,IHC 1:50-1:100
Molecular Weight:Calculated MW:159 kDa; Observed MW:159 kDa
Purification:Affinity Purification
Form:Liquid
Synonyms:RN3; ETOHI2; RNASEN; RANSE3L; RNASE3L; HSA242976

Applications

WB 1:2000-1:20000,IHC 1:50-1:100

Immunogen

A synthetic peptide of human Drosha

Target Background

This gene encodes a ribonuclease (RNase) III double-stranded RNA-specific ribonuclease and subunit of the microprocessor protein complex, which catalyzes the initial processing step of microRNA (miRNA) synthesis. The encoded protein cleaves the stem loop structure from the primary microRNA (pri-miRNA) in the nucleus, yielding the precursor miRNA (pre-miRNA), which is then exported to the cytoplasm for further processing. In a human cell line lacking a functional copy of this gene, canonical miRNA synthesis is reduced. Somatic mutations in this gene have been observed in human patients with kidney cancer. [provided by RefSeq, Sep 2016]

Synonyms:RN3; ETOHI2; RNASEN; RANSE3L; RNASE3L; HSA242976

Storage

Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.

Buffer

Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.

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