Immunological Sciences

DSCR 1 Rabbit Polyclonal Antibody

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Catalog Number:ABN10173
Conjugate:Unconjugated
Size:100μL
Concentration:1mg/ml
Host:Rabbit
Isotype:IgG
Clone:Polyclonal
Immunogen:The antiserum was produced against synthesized peptide derived from human RCAN1. AA range:201-250
Reactivity:Human,Mouse,Rat
Applications:WB 1:500-1:2000,ELISA 1:5000-1:20000
Molecular Weight:22kDa
Purification:Affinity purification
Form:Liquid
Synonyms:RCAN1; ADAPT78; CSP1; DSC1; DSCR1; Calcipressin-1; Adapt78; Down syndrome critical region protein 1; Myocyte-enriched calcineurin-interacting protein 1; MCIP1; Regulator of calcineurin 1

Applications

WB 1:500-1:2000,ELISA 1:5000-1:20000

Immunogen

The antiserum was produced against synthesized peptide derived from human RCAN1. AA range:201-250

Target Background

The protein encoded by this gene interacts with calcineurin A and inhibits calcineurin-dependent signaling pathways, possibly affecting central nervous system development. This gene is located in the minimal candidate region for the Down syndrome phenotype, and is overexpressed in the brain of Down syndrome fetuses. Chronic overexpression of this gene may lead to neurofibrillary tangles such as those associated with Alzheimer disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2013],function:Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A. Could play a role during central nervous system development.,induction:By calcium.,similarity:Belongs to the RCAN family.,tissue specificity:Highly expressed heart, brain and skeletal muscle. Also expressed in all other tissues.,

Synonyms:RCAN1; ADAPT78; CSP1; DSC1; DSCR1; Calcipressin-1; Adapt78; Down syndrome critical region protein 1; Myocyte-enriched calcineurin-interacting protein 1; MCIP1; Regulator of calcineurin 1

Storage

Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.

Buffer

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.

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