Immunological Sciences

E2F2 (6C14) Rabbit Monoclonal Antibody

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Catalog Number:MABN10252
Conjugate:Unconjugated
Size:100μL
Concentration:1mg/ml
Host:Rabbit
Isotype:IgG
Clone:Monoclonal
Immunogen:A synthetic peptide of human E2F2
Reactivity:Human,Mouse,Rat
Applications:WB 1:1000-1:5000,FC 1:100-1:500
Molecular Weight:48kDa
Purification:Affinity purification
Form:Liquid
Synonyms:De2f2; E2F transcription factor 2; E2F-2; Transcription factor E2F2;

Applications

WB 1:1000-1:5000,FC 1:100-1:500

Immunogen

A synthetic peptide of human E2F2

Target Background

Play an important role in the negative regulation of cell proliferation. Functional inactivation of Rb can be mediated either through mutation or as a consequence of interaction with DNA tumor virus-encoded proteins. The DRTF1/E2F complex functions in the control of cell-cycle progression from g1 to s phase. E2F2 binds specifically to RB1 in a cell-cycle dependent manner. Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from g1 to s phase. E2F2 binds specifically to RB1 in a cell-cycle dependent manner.

Synonyms:De2f2; E2F transcription factor 2; E2F-2; Transcription factor E2F2;

Storage

Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.

Buffer

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.

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