Immunological Sciences

EAAT2 Rabbit Monoclonal Antibody

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Catalog Number:MABN86785
Conjugate:Unconjugated
Size:100μL
Concentration:1mg/ml
Host:Rabbit
Isotype:IgG
Clone:Monoclonal
Immunogen:A synthetic peptide of mouse EAAT2
Reactivity:Mouse,Rat
Applications:WB 1:500-1:2000,IHC 1:200-1:2000,IP 1:20-1:50
Molecular Weight:Calculated MW:62 kDa; Observed MW:65 kDa
Purification:Affinity Purification
Form:Liquid
Synonyms:GLT1; Eaat2; GLT-1; MGLT1; AI159670; 1700091C19Rik; 2900019G14Rik

Applications

WB 1:500-1:2000,IHC 1:200-1:2000,IP 1:20-1:50

Immunogen

A synthetic peptide of mouse EAAT2

Target Background

Sodium-dependent, high-affinity amino acid transporter that mediates the uptake of L-glutamate and also L-aspartate and D-aspartate (PubMed:7698742, PubMed:7557442, PubMed:9373176). Functions as a symporter that transports one amino acid molecule together with two or three Na+ ions and one proton, in parallel with the counter-transport of one K+ ion. Mediates Cl- flux that is not coupled to amino acid transport; this avoids the accumulation of negative charges due to aspartate and Na+ symport (By similarity). Essential for the rapid removal of released glutamate from the synaptic cleft, and for terminating the postsynaptic action of glutamate (PubMed:9180080).

Synonyms:GLT1; Eaat2; GLT-1; MGLT1; AI159670; 1700091C19Rik; 2900019G14Rik

Storage

Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.

Buffer

Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.

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