Immunological Sciences

EDEM3 Rabbit Polyclonal Antibody

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Catalog Number:ABN10293
Conjugate:Unconjugated
Size:100μL
Concentration:1mg/ml
Host:Rabbit
Isotype:IgG
Clone:Polyclonal
Immunogen:Synthesized peptide derived from part region of human protein
Reactivity:Human,Mouse
Applications:WB 1:500-1:2000,ELISA 1:5000-1:20000
Molecular Weight:102kDa
Purification:Affinity purification
Form:Liquid

Applications

WB 1:500-1:2000,ELISA 1:5000-1:20000

Immunogen

Synthesized peptide derived from part region of human protein

Target Background

Quality control in the endoplasmic reticulum (ER) ensures that only properly folded proteins are retained in the cell through recognition and degradation of misfolded or unassembled proteins. EDEM3 belongs to a group of proteins that accelerate degradation of misfolded glycoproteins in the ER (Hirao et al., 2006 [PubMed 16431915]).[supplied by OMIM, Mar 2008],domain:Contains a protease-associated domain (PA) of unknown function.,function:Involved in endoplasmic reticulum-associated degradation (ERAD). Accelerates the glycoprotein ERAD by proteasomes. This process depends on mannose-trimming from the N-glycans. Seems to have alpha 1,2-mannosidase activity.,PTM:N-glycosylated.,similarity:Belongs to the glycosyl hydrolase 47 family.,similarity:Contains 1 PA (protease associated) domain.,

Storage

Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.

Buffer

Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.

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