Immunological Sciences

Eg5 (phospho Thr926) Rabbit Polyclonal Antibody

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Catalog Number:ABN04575
Conjugate:Unconjugated
Size:100μL
Concentration:1mg/ml
Host:Rabbit
Isotype:IgG
Clone:Polyclonal
Immunogen:The antiserum was produced against synthesized peptide derived from human KIF11/Eg5 around the phosphorylation site of Thr926. AA range:892-941
Reactivity:Human,Rat,Mouse
Applications:WB 1:500-1:2000,IHC 1:100-1:500,ICC/IF 1:50-1:200,ELISA 1:5000-1:10000
Molecular Weight:119kDa
Purification:Affinity purification
Form:Liquid
Synonyms:KIF11; EG5; KNSL1; TRIP5; Kinesin-like protein KIF11; Kinesin-like protein 1; Kinesin-like spindle protein HKSP; Kinesin-related motor protein Eg5; Thyroid receptor-interacting protein 5; TR-interacting protein 5; TRIP-5

Applications

WB 1:500-1:2000,IHC 1:100-1:500,ICC/IF 1:50-1:200,ELISA 1:5000-1:10000

Immunogen

The antiserum was produced against synthesized peptide derived from human KIF11/Eg5 around the phosphorylation site of Thr926. AA range:892-941

Target Background

kinesin family member 11(KIF11) Homo sapiens This gene encodes a motor protein that belongs to the kinesin-like protein family. Members of this protein family are known to be involved in various kinds of spindle dynamics. The function of this gene product includes chromosome positioning, centrosome separation and establishing a bipolar spindle during cell mitosis. [provided by RefSeq, Jul 2008],function:Motor protein required for establishing a bipolar spindle. Blocking of KIF11 prevents centrosome migration and arrest cells in mitosis with monoastral microtubule arrays.,PTM:Phosphorylated exclusively on serine during S phase, but on both serine and Thr-926 during mitosis, so controlling the association of KIF11 with the spindle apparatus (probably during early prophase). Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the kinesin-like protein family. BimC subfamily.,similarity:Contains 1 kinesin-motor domain.,subunit:Interacts with the thyroid hormone receptor in the presence of thyroid hormone. Component of a large chromatin remodeling complex, at least composed of MYSM1, PCAF, RBM10 and KIF11/TRIP5.,

Synonyms:KIF11; EG5; KNSL1; TRIP5; Kinesin-like protein KIF11; Kinesin-like protein 1; Kinesin-like spindle protein HKSP; Kinesin-related motor protein Eg5; Thyroid receptor-interacting protein 5; TR-interacting protein 5; TRIP-5

Storage

Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.

Buffer

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.

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