EMAP II Rabbit Monoclonal Antibody

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Catalog Number:MABN85535
Conjugate:Unconjugated
Size:100μL
Concentration:1mg/ml
Host:Rabbit
Isotype:IgG
Clone:Monoclonal
Immunogen:A synthetic peptide of human EMAP II
Reactivity:Human,Rat
Applications:WB 1:500-1:1000
Molecular Weight:Calculated MW: 34 kDa; Observed MW: 34 kDa
Purification:Affinity Purification
Form:Liquid
Synonyms:p43; HLD3; EMAP2; SCYE1; EMAPII; AIMP1

Applications

WB 1:500-1:1000

Immunogen

A synthetic peptide of human EMAP II

Target Background

Non-catalytic component of the multisynthase complex. Stimulates the catalytic activity of cytoplasmic arginyl-tRNA synthase. Binds tRNA. Possesses inflammatory cytokine activity. Negatively regulates TGF-beta signaling through stabilization of SMURF2 by binding to SMURF2 and inhibiting its SMAD7-mediated degradation. Involved in glucose homeostasis through induction of glucagon secretion at low glucose levels. Promotes dermal fibroblast proliferation and wound repair. Regulates KDELR1-mediated retention of HSP90B1/gp96 in the endoplasmic reticulum. Plays a role in angiogenesis by inducing endothelial cell migration at low concentrations and endothelian cell apoptosis at high concentrations. Induces maturation of dendritic cells and monocyte cell adhesion. Modulates endothelial cell responses by degrading HIF-1A through interaction with PSMA7.

Synonyms:p43; HLD3; EMAP2; SCYE1; EMAPII; AIMP1

Storage

Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.

Buffer

Purified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol.

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