Immunological Sciences

Eotaxin Rabbit Polyclonal Antibody

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Catalog Number:ABN10488
Conjugate:Unconjugated
Size:100μL
Concentration:1mg/ml
Host:Rabbit
Isotype:IgG
Clone:Polyclonal
Immunogen:The antiserum was produced against synthesized peptide derived from the Internal region of human CCL11. AA range:41-90
Reactivity:Human,Mouse,Rat
Applications:WB 1:500-1:2000,ELISA 1:10000-1:20000
Molecular Weight:11kDa
Purification:Affinity purification
Form:Liquid
Synonyms:CCL11; SCYA11; Eotaxin; C-C motif chemokine 11; Eosinophil chemotactic protein; Small-inducible cytokine A11

Applications

WB 1:500-1:2000,ELISA 1:10000-1:20000

Immunogen

The antiserum was produced against synthesized peptide derived from the Internal region of human CCL11. AA range:41-90

Target Background

This antimicrobial gene is one of several chemokine genes clustered on the q-arm of chromosome 17. Chemokines form a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of the N-terminal cysteine residues of the mature peptide. This chemokine, a member of the CC subfamily, displays chemotactic activity for eosinophils, but not mononuclear cells or neutrophils. This eosinophil-specific chemokine is thought to be involved in eosinophilic inflammatory diseases such as atopic dermatitis, allergic rhinitis, asthma and parasitic infections. [provided by RefSeq, Sep 2014],function:In response to the presence of allergens, this protein directly promotes the accumulation of eosinophils, a prominent feature of allergic inflammatory reactions. Binds to CCR3.,induction:By TNF-alpha, interleukin-1 alpha and interferon gamma.,online information:CCL11 entry,PTM:O-linked glycan consists of a Gal-GalNAc disaccharide which is mofified with up to 2 sialic acid residues.,similarity:Belongs to the intercrine beta (chemokine CC) family.,

Synonyms:CCL11; SCYA11; Eotaxin; C-C motif chemokine 11; Eosinophil chemotactic protein; Small-inducible cytokine A11

Storage

Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.

Buffer

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.

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