Immunological Sciences

Ephrin receptor A2 Rabbit Monoclonal Antibody

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Catalog Number:MABN87484
Conjugate:Unconjugated
Size:100μL
Concentration:1mg/ml
Host:Rabbit
Isotype:IgG
Clone:Monoclonal
Immunogen:Recombinant protein of mouse Ephrin receptor A2
Reactivity:Mouse,Rat
Applications:WB 1:500-1:2000,ICC/IF 1:20-1:50,FC 1:20-1:50,IP 1:20-1:50
Molecular Weight:Calculated MW:109 kDa; Observed MW:125 kDa
Purification:Affinity Purification
Form:Liquid
Synonyms:Eck; Myk2; Sek2; Sek-2; AW545284

Applications

WB 1:500-1:2000,ICC/IF 1:20-1:50,FC 1:20-1:50,IP 1:20-1:50

Immunogen

Recombinant protein of mouse Ephrin receptor A2

Target Background

Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Activated by the ligand ephrin-A1/EFNA1 regulates migration, integrin-mediated adhesion, proliferation and differentiation of cells. Regulates cell adhesion and differentiation through DSG1/desmoglein-1 and inhibition of the ERK1/ERK2 signaling pathway.

Synonyms:Eck; Myk2; Sek2; Sek-2; AW545284

Storage

Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.

Buffer

Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.

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