Immunological Sciences

ERAP1 Rabbit Monoclonal Antibody

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Catalog Number:MABN84579
Conjugate:Unconjugated
Size:100μL
Concentration:1mg/ml
Host:Rabbit
Isotype:IgG
Clone:Monoclonal
Immunogen:A synthesized peptide derived from human ERAP1
Reactivity:Human,Mouse,Rat
Applications:WB 1:1000-1:2000,IHC 1:100-1:200
Molecular Weight:Calculated MW: 107 kDa ; Observed MW: 100 kDa
Purification:Affinity Purification
Form:Liquid
Synonyms:ALAP; Aminopeptidase PILS; APPILS; Arts1; Endoplasmic reticulum aminopeptidase 1; ERAAP; ERAAP1; Erap1; PILSA; PILSAP;;ERAP1

Applications

WB 1:1000-1:2000,IHC 1:100-1:200

Immunogen

A synthesized peptide derived from human ERAP1

Target Background

Aminopeptidase that plays a central role in peptide trimming, a step required for the generation of most HLA class I-binding peptides. Peptide trimming is essential to customize longer precursor peptides to fit them to the correct length required for presentation on MHC class I molecules. Strongly prefers substrates 9-16 residues long. Rapidly degrades 13-mer to a 9-mer and then stops. Preferentially hydrolyzes the residue Leu and peptides with a hydrophobic C-terminus, while it has weak activity toward peptides with charged C-terminus.

Synonyms:ALAP; Aminopeptidase PILS; APPILS; Arts1; Endoplasmic reticulum aminopeptidase 1; ERAAP; ERAAP1; Erap1; PILSA; PILSAP;;ERAP1

Storage

Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.

Buffer

Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol.

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