Immunological Sciences

Ets-1 (phospho Thr38) Rabbit Polyclonal Antibody

No images available

Catalog Number:ABN04647
Conjugate:Unconjugated
Size:100μL
Concentration:1mg/ml
Host:Rabbit
Isotype:IgG
Clone:Polyclonal
Immunogen:The antiserum was produced against synthesized peptide derived from human ETS1 around the phosphorylation site of Thr38. AA range:11-60
Reactivity:Human,Mouse,Rat
Applications:WB 1:500-1:2000,IHC 1:100-1:300,ICC/IF 1:200-1:1000,ELISA 1:5000-1:20000
Molecular Weight:54kDa
Purification:Affinity purification
Form:Liquid
Synonyms:ETS1; EWSR2; Protein C-ets-1; p54

Applications

WB 1:500-1:2000,IHC 1:100-1:300,ICC/IF 1:200-1:1000,ELISA 1:5000-1:20000

Immunogen

The antiserum was produced against synthesized peptide derived from human ETS1 around the phosphorylation site of Thr38. AA range:11-60

Target Background

This gene encodes a member of the ETS family of transcription factors, which are defined by the presence of a conserved ETS DNA-binding domain that recognizes the core consensus DNA sequence GGAA/T in target genes. These proteins function either as transcriptional activators or repressors of numerous genes, and are involved in stem cell development, cell senescence and death, and tumorigenesis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Jul 2011],disease:ETS is responsible for erythroblast and fibroblast transformation. The juxtaposition of the interferon and c-ETS-1 proto-oncogene may be involved in the pathogenesis of human monocytic leukemia.,function:Transcription factor.,PTM:Sumoylated on Lys-15 and Lys-227, preferentially by SUMO2; which inhibits transcriptional activity.,PTM:Ubiquitinated; which induces proteasomal degradation.,similarity:Belongs to the ETS family.,similarity:Contains 1 ETS DNA-binding domain.,similarity:Contains 1 PNT (pointed) domain.,subunit:Interacts with MAF and MAFB (By similarity). Binds to DAXX. Interacts with UBE2I.,

Synonyms:ETS1; EWSR2; Protein C-ets-1; p54

Storage

Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.

Buffer

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.

No documents available.