Immunological Sciences

EYA1/4 Rabbit Polyclonal Antibody

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Catalog Number:ABN00509
Conjugate:Unconjugated
Size:100μL
Concentration:1mg/ml
Host:Rabbit
Isotype:IgG
Clone:Polyclonal
Immunogen:Synthetic peptide from human protein at AA range: 271-320
Reactivity:Human,Mouse
Applications:IHC 1:50-1:100,ELISA 1:5000-1:20000
Purification:Affinity Purification
Form:Liquid
Synonyms:Eyes absent homolog 1; Eyes absent homolog 4

Applications

IHC 1:50-1:100,ELISA 1:5000-1:20000

Immunogen

Synthetic peptide from human protein at AA range: 271-320

Target Background

Functions both as protein phosphatase and as transcriptional coactivator for SIX1, and probably also for SIX2, SIX4 and SIX5 (By similarity). Tyrosine phosphatase that dephosphorylates 'Tyr-142' of histone H2AX (H2AXY142ph) and promotes efficient DNA repair via the recruitment of DNA repair complexes containing MDC1. 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress.

Synonyms:Eyes absent homolog 1; Eyes absent homolog 4

Storage

Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.

Buffer

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.

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