Immunological Sciences

FACL4 (17M4) Rabbit Monoclonal Antibody

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Catalog Number:MABN10779
Conjugate:Unconjugated
Size:100μL
Concentration:1mg/ml
Host:Rabbit
Isotype:IgG
Clone:Monoclonal
Immunogen:Recombinant protein of human FACL4
Reactivity:Human
Applications:WB 1:500-1:2000,IHC 1:100-1:200,ICC/IF 1:20-1:50
Molecular Weight:79kDa
Purification:Affinity purification
Form:Liquid
Synonyms:ACS4; Acsl4; acyl CoA synthetase 4; FACL4; Fatty acid Coenzyme A ligase; LACS4; Long chain 4; long chain fatty acid Coenzyme A ligase 4; MRX63; MRX68;

Applications

WB 1:500-1:2000,IHC 1:100-1:200,ICC/IF 1:20-1:50

Immunogen

Recombinant protein of human FACL4

Target Background

Activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Preferentially uses arachidonate and eicosapentaenoate as substrates. Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoA for both synthesis of cellular lipids, and degradation via beta-oxidation (PubMed:24269233, PubMed:22633490, PubMed:21242590). Preferentially activates arachidonate and eicosapentaenoate as substrates (PubMed:21242590). Preferentially activates 8,9-EET > 14,15-EET > 5,6-EET > 11,12-EET. Modulates glucose- stimulated insulin secretion by regulating the levels of unesterified EETs (By similarity). Modulates prostaglandin E2 secretion (PubMed:21242590).

Synonyms:ACS4; Acsl4; acyl CoA synthetase 4; FACL4; Fatty acid Coenzyme A ligase; LACS4; Long chain 4; long chain fatty acid Coenzyme A ligase 4; MRX63; MRX68;

Storage

Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.

Buffer

Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% New type preservative N and 0.05% BSA.

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