Immunological Sciences

FADD Rabbit Monoclonal Antibody

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Catalog Number:MABN85554
Conjugate:Unconjugated
Size:100μL
Concentration:1mg/ml
Host:Rabbit
Isotype:IgG
Clone:Monoclonal
Immunogen:A synthetic peptide of mouse FADD
Reactivity:Human,Mouse
Applications:WB 1:500-1:1000,IHC 1:50-1:100
Molecular Weight:Calculated MW: 23 kDa; Observed MW: 28 kDa
Purification:Affinity Purification
Form:Liquid
Synonyms:Mort1/FADD

Applications

WB 1:500-1:1000,IHC 1:50-1:100

Immunogen

A synthetic peptide of mouse FADD

Target Background

Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis . Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling .

Synonyms:Mort1/FADD

Storage

Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.

Buffer

Purified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol.

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