FCGR3A Mouse Monoclonal Antibody

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Catalog Number:MABN85932
Conjugate:Unconjugated
Size:100μL
Concentration:1mg/ml
Host:Mouse
Isotype:Mouse IgG1
Clone:Monoclonal
Immunogen:This FCGR3A antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 60-88 amino acids from human FCGR3A.
Reactivity:Human
Applications:WB 1:500-1:1000
Molecular Weight:29.1kDa
Purification:Affinity Purification
Form:Liquid
Synonyms:Low affinity immunoglobulin gamma Fc region receptor III-A, CD16a antigen, Fc-gamma RIII-alpha, Fc-gamma RIII, Fc-gamma RIIIa, FcRIII, FcRIIIa, FcR-10, IgG Fc receptor III-2, CD16a, FCGR3A, CD16A, FCG3, FCGR3, IGFR3

Applications

WB 1:500-1:1000

Immunogen

This FCGR3A antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 60-88 amino acids from human FCGR3A.

Target Background

This gene encodes a receptor for the Fc portion ofimmunoglobulin G, and it is involved in the removal ofantigen-antibody complexes from the circulation, as well as otherother antibody-dependent responses. This gene (FCGR3A) is highlysimilar to another nearby gene (FCGR3B) located on chromosome 1.The receptor encoded by this gene is expressed on natural killer(NK) cells as an integral membrane glycoprotein anchored through atransmembrane peptide, whereas FCGR3B is expressed onpolymorphonuclear neutrophils (PMN) where the receptor is anchoredthrough a phosphatidylinositol (PI) linkage. Mutations in this genehave been linked to susceptibility to recurrent viral infections,susceptibility to systemic lupus erythematosus, and alloimmuneneonatal neutropenia. Alternatively spliced transcript variantsencoding different isoforms have been found for this gene.

Synonyms:Low affinity immunoglobulin gamma Fc region receptor III-A, CD16a antigen, Fc-gamma RIII-alpha, Fc-gamma RIII, Fc-gamma RIIIa, FcRIII, FcRIIIa, FcR-10, IgG Fc receptor III-2, CD16a, FCGR3A, CD16A, FCG3, FCGR3, IGFR3

Storage

Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.

Buffer

Purified antibody in PBS with 0.05% sodium azide.

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