FKBP12 (17C15) Rabbit Monoclonal Antibody

No images available

Catalog Number:MABN11001
Conjugate:Unconjugated
Size:100μL
Concentration:1mg/ml
Host:Rabbit
Isotype:IgG
Clone:Monoclonal
Immunogen:A synthetic peptide of human FKBP12
Reactivity:Human,Mouse,Rat
Applications:WB 1:500-1:2000
Molecular Weight:12kDa
Purification:Affinity purification
Form:Liquid
Synonyms:FKBP 12; FKBP 1A; FKBP1; FKBP12 Exip3; FKBP12C; fkbp1a; Immunophilin FKBP12; PKC12; PPIase FKBP1A; Rotamase;

Applications

WB 1:500-1:2000

Immunogen

A synthetic peptide of human FKBP12

Target Background

May play a role in modulation of ryanodine receptor isoform-1 (RYR-1), a component of the calcium release channel of skeletal muscle sarcoplasmic reticulum. There are four molecules of FKBP12 per skeletal muscle RYR. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Keeps in an inactive conformation TGFBR1, the TGF-beta type I serine/threonine kinase receptor, preventing TGF-beta receptor activation in absence of ligand. Recruits SMAD7 to ACVR1B which prevents the association of SMAD2 and SMAD3 with the activin receptor complex, thereby blocking the activin signal. May modulate the RYR1 calcium channel activity. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

Synonyms:FKBP 12; FKBP 1A; FKBP1; FKBP12 Exip3; FKBP12C; fkbp1a; Immunophilin FKBP12; PKC12; PPIase FKBP1A; Rotamase;

Storage

Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.

Buffer

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.

No documents available.