Immunological Sciences

Gab 1 (phospho Tyr627) Rabbit Polyclonal Antibody

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Catalog Number:ABN04715
Conjugate:Unconjugated
Size:100μL
Concentration:1mg/ml
Host:Rabbit
Isotype:IgG
Clone:Polyclonal
Immunogen:The antiserum was produced against synthesized peptide derived from human GAB1 around the phosphorylation site of Tyr627 AA range:611-643
Reactivity:Human,Mouse,Monkey
Applications:WB 1:500-1:2000,ELISA 1:5000-1:20000
Molecular Weight:110kDa
Purification:Affinity purification
Form:Liquid
Synonyms:GAB1; GRB2-associated-binding protein 1; GRB2-associated binder 1; Growth factor receptor bound protein 2-associated protein 1

Applications

WB 1:500-1:2000,ELISA 1:5000-1:20000

Immunogen

The antiserum was produced against synthesized peptide derived from human GAB1 around the phosphorylation site of Tyr627 AA range:611-643

Target Background

GRB2 associated binding protein 1(GAB1) Homo sapiens The protein encoded by this gene is a member of the IRS1-like multisubstrate docking protein family. It is an important mediator of branching tubulogenesis and plays a central role in cellular growth response, transformation and apoptosis. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008],function:Probably involved in EGF and insulin receptor signaling.,PTM:Phosphorylated on tyrosine residue(s) by the epidermal growth factor receptor (EGFR) and the insulin receptor (INSR). Tyrosine phosphorylation of GAB1 mediates interaction with several proteins that contain SH2 domains.,similarity:Belongs to the GAB family.,similarity:Contains 1 PH domain.,subunit:Interacts with GRB2 and with other SH2-containing proteins. Interacts with phosphorylated LAT2.,

Synonyms:GAB1; GRB2-associated-binding protein 1; GRB2-associated binder 1; Growth factor receptor bound protein 2-associated protein 1

Storage

Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.

Buffer

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.

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