Immunological Sciences

GAP1-InsP4 BP Rabbit Polyclonal Antibody

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Catalog Number:ABN11292
Conjugate:Unconjugated
Size:100μL
Concentration:1mg/ml
Host:Rabbit
Isotype:IgG
Clone:Polyclonal
Immunogen:The antiserum was produced against synthesized peptide derived from human RASA3. AA range:247-296
Reactivity:Human,Mouse,Rat
Applications:WB 1:500-1:2000,ELISA 1:20000-1:40000
Molecular Weight:95kDa
Purification:Affinity purification
Form:Liquid
Synonyms:RASA3; Ras GTPase-activating protein 3; GAP1(IP4BP); Ins P4-binding protein

Applications

WB 1:500-1:2000,ELISA 1:20000-1:40000

Immunogen

The antiserum was produced against synthesized peptide derived from human RASA3. AA range:247-296

Target Background

This gene encodes a protein that binds inositol 1,3,4,5-tetrakisphosphate and stimulates the GTPase activity of Ras p21. This protein functions as a negative regulator of the Ras signalling pathway. It is localized to the cell membrane via a pleckstrin homology (PH) domain in the C-terminal region. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016],function:Inhibitory regulator of the Ras-cyclic AMP pathway. Binds inositol tetrakisphosphate (IP4) with high affinity. Might be a specific IP4 receptor.,similarity:Contains 1 Btk-type zinc finger.,similarity:Contains 1 PH domain.,similarity:Contains 1 Ras-GAP domain.,similarity:Contains 2 C2 domains.,

Synonyms:RASA3; Ras GTPase-activating protein 3; GAP1(IP4BP); Ins P4-binding protein

Storage

Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.

Buffer

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.

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