GCLC Rabbit Monoclonal Antibody

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Catalog Number:MABN87067
Conjugate:Unconjugated
Size:100μL
Concentration:1mg/ml
Host:Rabbit
Isotype:IgG
Clone:Monoclonal
Immunogen:A synthetic peptide of human GCLC
Reactivity:Human,Mouse,Rat
Applications:WB 1:2000-1:20000,IP 1:20-1:50
Molecular Weight:Calculated MW:73 kDa; Observed MW:73 kDa
Purification:Affinity Purification
Form:Liquid
Synonyms:GCL; GCS; GLCL; GLCLC

Applications

WB 1:2000-1:20000,IP 1:20-1:50

Immunogen

A synthetic peptide of human GCLC

Target Background

Glutamate-cysteine ligase, also known as gamma-glutamylcysteine synthetase is the first rate-limiting enzyme of glutathione synthesis. The enzyme consists of two subunits, a heavy catalytic subunit and a light regulatory subunit. This locus encodes the catalytic subunit, while the regulatory subunit is derived from a different gene located on chromosome 1p22-p21. Mutations at this locus have been associated with hemolytic anemia due to deficiency of gamma-glutamylcysteine synthetase and susceptibility to myocardial infarction.[provided by RefSeq, Oct 2010]

Synonyms:GCL; GCS; GLCL; GLCLC

Storage

Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.

Buffer

Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.

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