Glutaminase (3F15) Rabbit Monoclonal Antibody

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Catalog Number:MABN11506
Conjugate:Unconjugated
Size:100μL
Concentration:1mg/ml
Host:Rabbit
Isotype:IgG
Clone:Monoclonal
Immunogen:A synthetic peptide of human Glutaminase
Reactivity:Human
Applications:WB 1:1000-1:2000,IHC 1:50-1:200,ICC/IF 1:100-1:200,FC 1:50-1:100
Molecular Weight:73kDa
Purification:Affinity purification
Form:Liquid
Synonyms:Glutaminase kidney isoform; GLS; GLS1, KGA; K-glutaminase; GAM; GAC; Glutaminase C; L-glutamine amidohydrolase;

Applications

WB 1:1000-1:2000,IHC 1:50-1:200,ICC/IF 1:100-1:200,FC 1:50-1:100

Immunogen

A synthetic peptide of human Glutaminase

Target Background

Catalyzes the first reaction in the primary pathway for the renal catabolism of glutamine. Plays a role in maintaining acid-base homeostasis. Regulates the levels of the neurotransmitter glutamate in the brain. Isoform 2 lacks catalytic activity. Isoform 1 and isoform 3 are activated by phosphate. Inhibited by BPTES. BPTES binds between subunits and favors dissociation of the tetramer into dimers. Catalyzes the first reaction in the primary pathway for the renal catabolism of glutamine. Plays a role in maintaining acid-base homeostasis. Regulates the levels of the neurotransmitter glutamate, the main excitatory neurotransmitter in the brain (PubMed:30575854, PubMed:30239721, PubMed:30970188).

Synonyms:Glutaminase kidney isoform; GLS; GLS1, KGA; K-glutaminase; GAM; GAC; Glutaminase C; L-glutamine amidohydrolase;

Storage

Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.

Buffer

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.

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