Immunological Sciences

GPR40 Rabbit Polyclonal Antibody

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Catalog Number:ABN11683
Conjugate:Unconjugated
Size:100μL
Concentration:1mg/ml
Host:Rabbit
Isotype:IgG
Clone:Polyclonal
Immunogen:The antiserum was produced against synthesized peptide derived from human FFAR1. AA range:185-234
Reactivity:Human,Monkey
Applications:WB 1:500-1:2000,ICC/IF 1:200-1:1000,ELISA 1:5000-1:20000
Molecular Weight:26kDa
Purification:Affinity purification
Form:Liquid
Synonyms:FFAR1; GPR40; Free fatty acid receptor 1; G-protein coupled receptor 40

Applications

WB 1:500-1:2000,ICC/IF 1:200-1:1000,ELISA 1:5000-1:20000

Immunogen

The antiserum was produced against synthesized peptide derived from human FFAR1. AA range:185-234

Target Background

This gene encodes a member of the GP40 family of G protein-coupled receptors that are clustered together on chromosome 19. The encoded protein is a receptor for medium and long chain free fatty acids and may be involved in the metabolic regulation of insulin secretion. Polymorphisms in this gene may be associated with type 2 diabetes. [provided by RefSeq, Apr 2009],function:Receptor for medium and long chain saturated and unsaturated fatty acids. Binding of the ligand increase intracellular calcium concentration and amplify glucose-stimulated insulin secretion. The activity of this receptor is mediated by G-proteins that activate phospholipase C. Seems to act through a G(q) and G(i)-mediated pathway.,similarity:Belongs to the G-protein coupled receptor 1 family.,tissue specificity:Expressed abundantly in pancreatic beta cells.,

Synonyms:FFAR1; GPR40; Free fatty acid receptor 1; G-protein coupled receptor 40

Storage

Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.

Buffer

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.

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