Immunological Sciences

GRB7 (4L2) Rabbit Monoclonal Antibody

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Catalog Number:MABN11753
Conjugate:Unconjugated
Size:100μL
Concentration:1mg/ml
Host:Rabbit
Isotype:IgG
Clone:Monoclonal
Immunogen:Recombinant protein of human GRB7
Reactivity:Human
Applications:WB 1:1000-1:10000,IHC 1:200-1:500,IF-P 1:200-1:500
Molecular Weight:60kDa
Purification:Affinity purification
Form:Liquid
Synonyms:B47; Epidermal growth factor receptor GRB 7; GRB7 adapter protein; GRB7;

Applications

WB 1:1000-1:10000,IHC 1:200-1:500,IF-P 1:200-1:500

Immunogen

Recombinant protein of human GRB7

Target Background

Interacts with the cytoplasmic domain of the epidermal growth factor receptor which is then inhibited. The interaction is mediated by the SH2 domain. Also binds to ERBB2. Adapter protein that interacts with the cytoplasmic domain of numerous receptor kinases and modulates down-stream signaling. Promotes activation of down-stream protein kinases, including STAT3, AKT1, MAPK1 and/or MAPK3. Promotes activation of HRAS. Plays a role in signal transduction in response to EGF. Plays a role in the regulation of cell proliferation and cell migration. Plays a role in the assembly and stability of RNA stress granules. Binds to the 5'UTR of target mRNA molecules and represses translation of target mRNA species, when not phosphorylated. Phosphorylation impairs RNA binding and promotes stress granule disassembly during recovery after cellular stress (By similarity).

Synonyms:B47; Epidermal growth factor receptor GRB 7; GRB7 adapter protein; GRB7;

Storage

Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.

Buffer

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.

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