Immunological Sciences

GRF00002

Recombinant Human IL-1 beta Protein is greater than 95% as determined by SEC-HPLC.

Recombinant Human IL-1 beta Protein is greater than 95% as determined by SEC-HPLC.

Catalog Number:GRF00002
Size:20 ug
Form:lyophilized
Synonyms:IL-1;IL1-BETA;IL1F2;IL1 beta;IL1B
Species:E. coli
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Recombinant Human IL-1 beta Protein

Target Background

Interleukin-1 beta (IL1 beta or IL1B) also known as catabolin, is a member of the interleukin 1 cytokine family.This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. The induction of cyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity.

Synonyms:IL-1;IL1-BETA;IL1F2;IL1 beta;IL1B

Storage

Store at -20℃.Store the lyophilized protein at -20℃ to -80 ℃ up to 1 year from the date of receipt. After reconstitution, the protein solution is stable at -20℃ for 3 months, at 2-8℃ for up to 1 week.

Recombinant Human IL-1 beta Protein is greater than 95% as determined by SEC-HPLC.

Recombinant Human IL-1 beta Protein is greater than 95% as determined by SEC-HPLC.

Recombinant Human IL-1 beta promotes the proliferation of D10.G4.1 mouse helper T cells. The ED50 for this effect is 6.04-24.16 pg/mL, corresponding to a specific activity of 4.14×107~1.66×108 units/mg.

Recombinant Human IL-1 beta Protein was determined by SDS-PAGE under reducing conditions with Coomassie Blue.

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