Immunological Sciences

GRF01637

Recombinant Human CXCL12/SDF-1 Protein chemoattract MOLT4 cells. The ED50 for this effect is 11.47-45.86 ng/mL, corresponding to a specific activity of 2.18×104 ~8.72×104 units/mg.

Recombinant Human CXCL12/SDF-1 Protein chemoattract MOLT4 cells. The ED50 for this effect is 11.47-45.86 ng/mL, corresponding to a specific activity of 2.18×104 ~8.72×104 units/mg.

Catalog Number:GRF01637
Size:10 ug, 20 ug
Form:lyophilized
Synonyms:IRH; PBSF; SDF1; TLSF; TPAR1; SCYB12;CXCL12
Species:Pichia
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Recombinant Human CXCL12/SDF-1 Protein

Target Background

Acts as a positive regulator of monocyte migration and a negative regulator of monocyte adhesion via the LYN kinase. Stimulates migration of monocytes and T-lymphocytes through its receptors, CXCR4 and ACKR3, and decreases monocyte adherence to surfaces coated with ICAM-1, a ligand for beta-2 integrins. SDF1A/CXCR4 signaling axis inhibits beta-2 integrin LFA-1 mediated adhesion of monocytes to ICAM-1 through LYN kinase. Inhibits CXCR4-mediated infection by T-cell line-adapted HIV-1. Plays a protective role after myocardial infarction. Induces down-regulation and internalization of ACKR3 expressed in various cells. Has several critical functions during embryonic development; required for B-cell lymphopoiesis, myelopoiesis in bone marrow and heart ventricular septum formation. Stimulates the proliferation of bone marrow-derived B-cell progenitors in the presence of IL7 as well as growth of stromal cell-dependent pre-B-cells (By similarity).

Synonyms:IRH; PBSF; SDF1; TLSF; TPAR1; SCYB12;CXCL12

Storage

Store at -20℃.Store the lyophilized protein at -20℃ to -80 ℃ up to 1 year from the date of receipt. After reconstitution, the protein solution is stable at -20℃ for 3 months, at 2-8℃ for up to 1 week.

Recombinant Human CXCL12/SDF-1 Protein chemoattract MOLT4 cells. The ED50 for this effect is 11.47-45.86 ng/mL, corresponding to a specific activity of 2.18×104 ~8.72×104 units/mg.

Recombinant Human CXCL12/SDF-1 Protein chemoattract MOLT4 cells. The ED50 for this effect is 11.47-45.86 ng/mL, corresponding to a specific activity of 2.18×104 ~8.72×104 units/mg.

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